Diphenhydramine (Benadryl) usually counteracts the stimulant effect of pseudoephedrine, and is one of the main ingredients in NyQuil (along with a cough suppres

Diphenhydramine (Benadryl) usually counteracts the stimulant effect of pseudoephedrine, and is one of the main ingredients in NyQuil (along with a cough suppressant). That combination is what made NyQuil so formidable before the pseudo-pocalypse, but you can recreate the effect just by taking both. However nasal sprays like Afrin are just as effective and don’t have nearly the stimulant effect, especially when used with NyQuil