It's more like "made uninhabitable for humans/current life". I'm sure after a few hundred million years some new forms of biodiversity would arise to replace wh

It's more like "made uninhabitable for humans/current life". I'm sure after a few hundred million years some new forms of biodiversity would arise to replace what can't survive whatever disaster we leave behind (short of sundering the earth into multiple pieces and pushing us out of our current orbit). One model of genotypic diversity is that it is a mostly random walk through a huge multidimensional space, and while it's unlikely to revisit the same point twice, nature has only explored a small fraction of the total space.