Here is a very general description of the system. The DNA probe has: - conjugated voltage sensitive dye - a conjugated reference dye - a targeting motif Th

Here is a very general description of the system. The DNA probe has: - conjugated voltage sensitive dye - a conjugated reference dye - a targeting motif The targeting motif allows it to go into a specific organelle. The ratio of voltage sensitive signal to reference dye signal is used as a read-out. They calibrated and confirmed the probe by inducing artificial membrane potential changes and seeing if the read-out signal correlates. It's a cool system.