3 ms·
"The team found that an antibiotic that killed P. gingivalis did this too, but less effectively, and the bacteria rapidly developed resistance."
by karussell 8y ago
"The team found that an antibiotic that killed P. gingivalis did this too, but less effectively, and the bacteria rapidly developed resistance."
- Latteland 8y agoThe linked paper says besides the bacteria developing resistance to antibiotics, they found Kgp inhibitors seemed to continue to work. "We have demonstrated that P. gingivalis develops rapid resistance to a broad-spectrum antibiotic, moxifloxacin, but not to the Kgp inhibitor COR388. Therefore, with the growing concern about widespread antibiotic resistance (103), ..., an antivirulence factor inhibition approach to treatment of P. gingivalis is the most promising path while reducing pressures for resistance."