> CGRP has been shown to activate the mitogen-activated protein kinases (MAPKs), which are phosphorylated in some tissues following CGRP activation. This can le

> CGRP has been shown to activate the mitogen-activated protein kinases (MAPKs), which are phosphorylated in some tissues following CGRP activation. This can lead to the proliferation of gingival fibroblasts (215), via PKA-dependent and -independent pathways (214). CGRP can protect cultured vascular smooth muscle cells from oxidative stress-induced apoptosis by a signaling pathway involving activation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 MAPKs (354). (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187032/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187032/) To simplify, migraines are a result of oxidative stress, and CGRP helps reduce oxidative stress. Seems a bit reckless to me to be decreasing CGRP Anecdotally, while I've never had a proper migraine (but my mom does occasionally), I used to get terrible headaches. I've completely eliminated this by eating an anti inflammatory diet and taking a collagen supplement. Glycine is the main amino acid in collagen, many (most?) people are deficient, and is used to make glutathione, you body's natural antioxidant and detoxer.