Yes, and these aren't that easy to manage, but still doable, but thanks to a really helpful and big community it's easier. Some tools allow for regex, wildcards

Yes, and these aren't that easy to manage, but still doable, but thanks to a really helpful and big community it's easier. Some tools allow for regex, wildcards and similar. The bigger issue comes from the likes of Google/YouTube/Facebook who host their ads on the same domain as their main website, ergo, if you want to block the ad domains, you'll be blocked the main domains as a whole. In this case, the only way to block ads is through an in-browser addon.