its like taking a low resolution photography of 23 chromosomes and X and Y plus the circular mitochondrial genome. The higher the resolution the more expensive

its like taking a low resolution photography of 23 chromosomes and X and Y plus the circular mitochondrial genome. The higher the resolution the more expensive it is and more data and more difficult to interpret. If the feature you interested in is large and unique then a blurry picture may be good enough for example recognize a human body from few yards away, as the features become more refined and more diverse like a face, you can still have little blurr but you need to recognize the facial dimensions extensively to be useful. And if you want to see skin lesions then you want a high resolution pictures to distinguish which type it is... sampling is a high resolution photo with large holes in it, a full sequencing is a full photograph with varying resolution and quality etc. There are still some areas of the genome that are inaccessible even with full sequencing. Improvements are being made with long read sequencing.