I'd contest that this is everything that you need to know. Or perhaps more accurately, everything I need to know. It's certainly not intended to be exhaustive

I'd contest that this is everything that you need to know. Or perhaps more accurately, everything I need to know. It's certainly not intended to be exhaustive and I am definitely not a network engineer but I think you could operate at a reasonable scale within a single well laid out VPC. Of course there'll be a point for peering etc. but you might not need that.