Qt with or without QML should definitely be considered. Granted, I can't say I've ever made more than a toy application in Qt (via Python and PySide). A third

Qt with or without QML should definitely be considered. Granted, I can't say I've ever made more than a toy application in Qt (via Python and PySide). A third option if you're too afraid of C++ or one of the Qt bindings, and you really need something web-like, is JavaFX.