3 ms·
Nice! More recently (Jan 2019) from the same group: De novo Design of Potent and Selective Mimics of IL-2 and IL-15: https://www.nature.com/articles/s41586-01
by vstuart 8y ago
Nice! More recently (Jan 2019) from the same group:
De novo Design of Potent and Selective Mimics of IL-2 and IL-15: https://www.nature.com/articles/s41586-018-0830-7 https://www.nature.com/articles/s41586-018-0830-7
Lab's accompanying media post: https://www.bakerlab.org/index.php/2019/01/09/potent-anti-cancer-proteins-fewer-side-effects/ https://www.bakerlab.org/index.php/2019/01/09/potent-anti-ca...
" Potent anti-cancer proteins with fewer side effects. Today we report in Nature the first de novo designed proteins with anti-cancer activity. These compact molecules were designed to stimulate the same receptors as IL-2, a powerful immunotherapeutic drug, while avoiding unwanted off-target receptor interactions. ..."
A remarkable and powerful achievement.