The headline is a bit misleading and if you look at the landscape of cancer immunotherapy research you will see this generalization does not hold at all i.e. tu

The headline is a bit misleading and if you look at the landscape of cancer immunotherapy research you will see this generalization does not hold at all i.e. tumor mutational burden is not necessarily a good predictor of response in all types of tumors. See apathy's response above. W.r.t spontaneous remission, there have been a few lines of research that would seem to lend credence to your hypothesis (e.g. - see http://www.fevertherapy.eu/ http://www.fevertherapy.eu/) but it has never been studies systematically enough to draw any conclusions one way or the other.