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The article intimates at the answer to why alcohol withdrawal can be more difficult and dangerous than hard drugs. Recall the part where they explain how cocain
by Perceval 16y ago
The article intimates at the answer to why alcohol withdrawal can be more difficult and dangerous than hard drugs. Recall the part where they explain how cocaine and heroin and speed only work on one neurotransmitter principally, whereas alcohol works on a large number (dopamine, seratonin, GABA, norepinephrine, etc)—scalpel vs. hand grenade.
So in withdrawing from cocaine or heroin or nicotine you can prescribe someone a drug that works on the relevant receptors, blocking or even reversing the effect of the drug. For example, I recall that buproprion is prescribed to treat nicotine addiction because it blocks nicotine's effect on norepinephrine receptors. The strategy with heroin or cocaine withdrawal might be similar, targeting the opioid or dopamine receptors respectively.
Contrast this with the wider effects of alcohol, influencing half a dozen or more neurotransmitters. There's no easy strategy to target the chemical dependencies your brain has built up because there're too many.
So while heroin and cocaine are more immediately addictive than alcohol, withdrawal from alcoholism (once it has developed) can be just as dangerous and sometimes more so.