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This is our immortality we are discounting for a fistful of resources. Sequencing previously unknown sea life has allowed us to find 6 of the 13 genes we need t
by Iv 8y ago
This is our immortality we are discounting for a fistful of resources. Sequencing previously unknown sea life has allowed us to find 6 of the 13 genes we need to get rid of mitochondria, a necessary step in preventing cells aging.
(Longer, more detailed version) Early in our evolutionary history, when we were still unicellular organisms, we absorbed another life form that came to live in symbiosis with us. Mitochondrion are like cells inside our cells. They reproduce and are transmitted through the mother. They code for a few proteins we need to survive. Their malfunctions is believed to play a role in some degenerative diseases such as Parkinson or Alzheimer.
Unfortunately, they did not evolve the same complex self-repair mechanisms that our nucleus did. A lot of factors cause mitochondrial DNA to degrade. This gave an evolutionary incentive to find ways for the nucleus to encode genes for similar proteins so that less functions may be impaired by mitochondrial development.
It can't be the same gene though, for reasons that are a bit complicated. As a summary let's say that the membrane of mitochondrion is easier to cross that the one of the nucleus, so you need a kind of shape hack to get it through. Imagine that you are asked to copy a vehicle, but the copy also has to be able to unfold in a way that allows through to go through a manhole. Not trivial.
Luckily, the pressure to find these genetic recipes exists in all the eukaryote domain, which includes all the animals and the plans (and a few other things). That includes a huge number of organisms that we have never sequences or even named. Recipes that work for their nucleus has a good chance of being able to work with ours. So far we found recipes for 6 of the 13 genes we need, but every time a species disappear without us being able to check for these, we may be kissing our ticket to eternity goodbye.
These 13 genes are vital, but I must also add that every gene in living organisms is a recipe for a useful molecule. Remember that spider silk has a higher tensile strength than steel, and that we know next to nothing about organisms that survive in high pressure environments.
Killing species for short-term resources is as dumb as uncovering an encyclopedia written by advanced aliens and burning it for heat.
Could we somehow find these genes through simulation? Unlikely. The protein folding problem is a n-body problem and a billion years of evolution did not find a smarter way than brute force to solve it. And by the way, it ran a brute force algorithm on a billion year in a lab the size of a planet. Realize the incredible value of this rainbow table.
Really, even if we do not care at all about biodiversity on the philosophical level, we should care about it on a very egoistical level. It is likely to be the most precious thing our planet contains: solution to uncomputable problems.
- njarboe 8y agoI agree messing around with the sea-floor will probably mess up the local area, but the area of the Ocean is huge. I am not a micro-biologist but your ideas about the importance and complexity of mitochondria is under estimated. The primary function of mitochondria is the production of ATP which is then used for energy throughout the rest of the cell. Protein coding by the mitochondria, I would guess, is just a way that this very important part of a cell can have a more powerful feedback loop with the rest of the cell. Unless we can create some kind of nano-bot replacement for the creation of ATP in the cell, with all the right feedback loops, etc., just coding the proteins that the mitochondria codes for in the cell DNA will not work at all.
- klyrs 8y agoThat sounds like a technology that will be extremely expensive, accessible only by the ultra-rich and used by the ultra-rich to further concentrate their power and influence. Yet another arena where scientists refuse to look at the historical context of inequality and thereby contribute to worsening oppression. I'm sad about what people want to do to the ocean floor but certainly not because of your argument
- Iv 8y agoThere is literally zero reasons to believe that. It is a bit tiring to hear Americans believe that all new medical process will be prohibitively expensive because they can't imagine a sane healthcare system. Experimental treatments are always expensive. Once you industrialize them, they become cheap. And it turns out that aging is a pretty common disease that many people would be ready to treat.