I don't know about "mitochondrial disturbances", however fructose gets metabolized only in the liver, so very unlike glucose or saturated or monounsaturated fat

I don't know about "mitochondrial disturbances", however fructose gets metabolized only in the liver, so very unlike glucose or saturated or monounsaturated fat. Fructose competes in the liver with other nutrients and in large quantities it becomes toxic, leading to a fatty liver, or a fatty pancreas. And as I wrote elsewhere, a fatty liver or a fatty pancreas are the best predictors of obesity or diabetes. Our body is very efficient at processing glucose, so glucose is very different from fructose. This is why honey is much healthier than table sugar, because of the glucose/fructose ratio. Also "the dose makes the poison". Eating a banana or two per day won't screw your liver, but drinking Coca Cola daily will.