I wrote my thesis (200 pages) in LaTeX and I cannot imagine not having to do the final touch ups in LaTeX. You tend to get lots of line break issues, figure loc

I wrote my thesis (200 pages) in LaTeX and I cannot imagine not having to do the final touch ups in LaTeX. You tend to get lots of line break issues, figure location and orientation and spacing issues, vertical spacing issues, that you have to touch up to make it look nice. It sounds incredibly impractical to do your writing in markdown and then use pandoc to convert to LaTeX, do dozens of touch ups, and then get your final output, send to your reviewers, get your reviews and recommended edits, do more edits (okay, now I can't go back to markdown anymore and redo the whole conversion process), more touch ups, rinse and repeat a few dozen times with your reviewers. Might as well stick with LaTeX in the first place.