The one trend I'm sensing is that difficult human/technology problems that were once thought of as 'solved' are now becoming hard again. Think of microprocessor

The one trend I'm sensing is that difficult human/technology problems that were once thought of as 'solved' are now becoming hard again. Think of microprocessors as a model, for years Moore's law was running smoothly and you could set you watch on upgrading your PC at least once every 3 years. The rate of improvement is slowing down as it becomes more capital intensive to advance chips, all the while the demand for performant chips is increasing. We will need another transistor level breakthrough to fuel the next 25 years of microprocessor based improvement. You can see this trend also with energy on a longer timescale: oil and coal is the fuel that propelled the industrial revolution and human advancement for the past 150 years. Climate change demands that new forms of energy take the forefront: innovations in nuclear power and electricity transportation and storage are needed. If I were in an investor with a ton of cash I would look to past and explore innovations and ideas around the industrial revolution and try to apply those models to the next 50 years. I really do think we are approaching a similar point in human history where there will need to be a large set of fundamentally new discoveries to continue pushing us forward. As an aside, I think "devsumer" is also a great area. Maybe I'm in a bubble, but I can't think of a labor force that is producing as much global value (in agreed upon terms) as software developers, creating tools for this labor force is going to continue to be big business.