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The closest thing to this is probably DNA origami for nanoscale structures. Beyond that, were not quite at the place where we can compute desired phenotype ->
by subcosmos 8y ago
The closest thing to this is probably DNA origami for nanoscale structures.
Beyond that, were not quite at the place where we can compute desired phenotype -> genetic code, except for when single enzymatic reactions are all you are doing. Going bigger requires understanding the nonlinear complexities of the system in much deeper detail.
- jfarlow 8y agoWe can and do go from phenotype -> genetic code as long as the phenotypic ask is something we have some familiarity with. There are enough examples out there that even though the toolbox is still small, there's plenty of new things we can rationally design - even if our success rate is not 100%. Transcription Factor + GFP -> green transcription factor -> codon-optimized plasmid Membrane tag + light-activated conformational change + cytoskeleton -> optogenetic mechanotransduction Small-molecule-activated degradation domain + transcription factor -> chemically-induced genetic switch. And though there's still a bit of trial and error to debug which/how those components go together, it's a common enough thing to be reasonably accessible.
- agumonkey 8y agoyou work in this field ? It's of the most fascinating one I've seen..