What should be worked on is fairly easy to figure out using the inversion technique. Think about what will happen if we do NOT work on something and assign high

What should be worked on is fairly easy to figure out using the inversion technique. Think about what will happen if we do NOT work on something and assign highest priorities to tasks that will cause catastrophic results if we do NOT work on them. If you do that, you'll quickly find that healthcare largely doesn't matter right now: you might score a victory fighting malaria, but Earth will be a scorched desert because of global warming caused by our carbon emissions. So, I'd say that the most important thing that we could possibly work on right now is removing carbon from the air, because if we do not, our grandchildren will have serious problems, and their children might not have a planet to live on. But that's not what you really asked, right? You wanted to know whether to work on Big Problems. And from your description it seems like you have the same problem all perfectionists do: how do I even get started if the problem is so Big and Complex that it's likely I'll never even make a dent? Well, if you ever figure that one out, be sure to let me know.