We work on the things that are at the intersection of what we want to work on, what we are capable of working on (contributing to), and what the world (customer

We work on the things that are at the intersection of what we want to work on, what we are capable of working on (contributing to), and what the world (customers) want to have us work on. It's the same thing with charitable giving. Give to the cause that will sustain your passion and connection to the cause. Disease in third world countries may reduce the most suffering in the world, but helping others in your own first world community is a "good" that should not be discounted.