I had a really long reply typed up with some specific workflow problems. But you can see people complain elsewhere in this thread about how Adobe handles stuff

I had a really long reply typed up with some specific workflow problems. But you can see people complain elsewhere in this thread about how Adobe handles stuff like this. The basic problem is that the color space for blending is an application setting (can't be specified in the file) and higher bit depths will double or triple your file size.