3 ms·

As someone who works at a place mentioned in this article, I can tell you, we do not subscribe the belief set he says we do, and actually, likely agree with the

As someone who works at a place mentioned in this article, I can tell you, we do not subscribe the belief set he says we do, and actually, likely agree with the author that cancer is a systemic disease that involves not only the tumor, but also the TME, the peripheral immune system, other organs, etc. The "tumor only" view of cancer is dead and has been very a while, and even "Silicon Valley" knows this. Also, for those here: checkpoint inhibitor therapies are a "better approach" that incorporate a systemic activation of a patient's immune system to kill cancer, and they really, really work (see: Nobel Prize this year to Jim Allison).

shaneofalltrad 8y ago
This is also not perfect, as for example those with autoimmune conditions will not always work and can actually get worse under immunotherapy. My wife has stage 4 lung cancer due to Scleroderma immunosuppression medication and is struggling with the treatments due to the reactions ( immune system attacking non cancer cells ).
- randcraw 8y ago
  As a cancer survivor, my heart goes out to you both. As someone who also works for a company that makes a checkpoint inhibitor, one of our chief efforts is to better understand what makes them work for some patients and not others. Not only would this knowledge serve the lucky patients by tuning their therapy for better efficacy and lesser side effects, but would help us know more about how CPIs fail, and ideally, to enable their use in the many, as yet, unlucky patients.