>mechanisms that cannot be evaded and which occur in most or all cancers. The problem with this is that if something cannot be evaded(is probably "core" to the

>mechanisms that cannot be evaded and which occur in most or all cancers. The problem with this is that if something cannot be evaded(is probably "core" to the cell) or occurs in most cancers, it also most likely occurs in healthy cells as well. 10000s of drugs are made each year which kill cancer cells, but the problem is that they are not specific to the cancer and kill everything else too. The holy grail in cancer drug development is to develop a drug that ONLY kills cancer cells and leaves everything else alone. We have yet to make one of these. >The canonical example is to interfere in telomerase and ALT telomere lengthening. Cancer cells do lots of random things. After all, they are just a collection of "bugs" that occurred randomly in such a way that they present symptoms we recognize as cancer. Just because they express telomerase doesn't mean its important. Im sure they express lots of random other things too. "Obvious" solutions like this, have been tested by 100 people by now, and since we haven't heard anything, we can safely assume it doesn't work.