5 ms·

OTOH acetaminophen is known to be toxic; is there an alternative here for non narcotic inflammation, fever, and pain relief that is shown NOT to have tradeoffs

by drb91 8y ago

OTOH acetaminophen is known to be toxic; is there an alternative here for non narcotic inflammation, fever, and pain relief that is shown NOT to have tradeoffs for use?

tchaffee 8y ago
No tradeoffs? I don't think such a thing exists. Aspirin kills people every year. The only pain reliever I know of that has never killed anyone is cannabis. I don't think it does much for fever though?
- sureaboutthis 8y ago
  Inhaling smoke into your lungs is never a good thing. Your lungs (cough) are trying to tell you something.
  - tchaffee 8y ago
    Where did I say anything about smoking? And I also didn't say cannabis has no tradeoffs either. But it won't kill you. That's a pretty strong pro in my book if you are looking for occasional pain relief.
    - sureaboutthis 8y ago
      You didn't say anything about not smoking it either.
  - deleted 8y ago
    [deleted]
arcticbull 8y ago
Naproxen / Aleve?
- sparn5 8y ago
  The naproxen molecule is very similar to ibuprofen, so I expect it would have similar effects.
- wool_gather 8y ago
  The sodium part of naproxen sodium is a concern for some people.
conanthe 8y ago
Kratom / Cannabis oh wait these are illegal so big pharma can milk their poisons.
- mirimir 8y ago
  As soon as they're legal enough, they'll be milked too. I mean, you know, analogs tweaked for higher potency, etc.
- cycrutchfield 8y ago
  Cannabis causes low T and gynecomastia, so not really
  - naasking 8y ago
    I looked for studies supporting your statement. The evidence is conflicting, and there appears to be no conclusive evidence one way or the other, although some people certainly are fond of repeating this as if it's fact.
    - sodosopa 8y ago
      Still appears questionable - A few studies and more information included in this article. https://www.mdmag.com/medical-news/is-there-a-link-between-low-testosterone-and-chronic-marijuana-useandrwe https://www.mdmag.com/medical-news/is-there-a-link-between-l...
  - conanthe 8y ago
    Citations are "studies" from Nixon era. "Scientists" only could be allowed to study cannabis for bad effects and that was the only way to get funding. This is all crap my friend.
- braythwayt 8y ago
  Here in Canada, Big Pharma are falling over themselves to get into the Cannabis business. I honestly think the obstacle to Cannabis legalization in the US is social conservatism, not industrial lobbying.
ada1981 8y ago
I just started using CBD, it’s possible it’s just placebo, but I feel no more pain in my joints in the Am, am more relaxed, less anxious, more agreeable and more aware of my body. I’m taking 5Mg capsules 2x a day.
Flashtoo 8y ago
Acetaminophen/paracetamol is really only toxic in higher doses due to its metabolism, as only the intermediate metabolite NAPQI is toxic, but that cannot build up in low doses.
- drb91 8y ago
  Still, it seems just as easy to have too much of a dose or acetaminophen in a single day as it is to use ibuprofen continually for an extended period of time.
naasking 8y ago
> OTOH acetaminophen is known to be toxic This is news to me. What exactly does "toxic" mean? Do you have a citation I can read? Acetaminophen is not for inflammation anyway.
- cyphar 8y ago
  Paracetamol (or acetaminophen) can cause liver failure if you take too high a dose[1] (this is one of the reasons you are told not to drink alcohol when taking paracetamol -- if your liver is struggling to process alcohol you're more susceptible to liver failure). In fact, paracetamol poisoning is the primary cause of death in overdoses (in the US, UK, Australia and New Zealand)[2]. And in 2006, [3] found it was the most commonly used compound for intentional overdosing (i.e. suicide by overdose). But of course, this depends on taking a very high dose -- paracetamol isn't dangerous in moderate doses. [1]: https://en.wikipedia.org/wiki/Paracetamol_poisoning https://en.wikipedia.org/wiki/Paracetamol_poisoning [2]: https://www.ncbi.nlm.nih.gov/pubmed/18312195 https://www.ncbi.nlm.nih.gov/pubmed/18312195 [3]: https://www.ncbi.nlm.nih.gov/pubmed/16805658 https://www.ncbi.nlm.nih.gov/pubmed/16805658
  - naasking 8y ago
    > Paracetamol (or acetaminophen) can cause liver failure if you take too high a dose Sure, and drinking too much water causes hypernutremia that can also kill you. Toxicity is always dose dependent, so the initial unqualified claim seemed to imply toxicity at normal dosages.
    - cyphar 8y ago
      Botulinum toxin (botox) doesn't kill most people in the standard dosage, but it is obviously toxic (it's in the name). Paracetamol poisoning is fairly common, hypernutremia isn't. Don't get me wrong, I disagree with the original statement that paracetamol is toxic (with the implication that this is a reason not to use it in normal dosages). But it's definitely not harmless.
      - 8y ago
solitus 8y ago
Cannabis with a higher concentration of CBD than THC. I like a ~2:1 ratio.
floatingatoll 8y ago
Ice. (As in, frozen water.)

by drb91 8y ago

OTOH acetaminophen is known to be toxic; is there an alternative here for non narcotic inflammation, fever, and pain relief that is shown NOT to have tradeoffs for use?

tchaffee 8y ago

No tradeoffs? I don't think such a thing exists. Aspirin kills people every year. The only pain reliever I know of that has never killed anyone is cannabis. I don't think it does much for fever though?

sureaboutthis 8y ago
Inhaling smoke into your lungs is never a good thing. Your lungs (cough) are trying to tell you something.
- tchaffee 8y ago
  Where did I say anything about smoking? And I also didn't say cannabis has no tradeoffs either. But it won't kill you. That's a pretty strong pro in my book if you are looking for occasional pain relief.
  - sureaboutthis 8y ago
    You didn't say anything about not smoking it either.
- deleted 8y ago
  [deleted]

arcticbull 8y ago

Naproxen / Aleve?

sparn5 8y ago
The naproxen molecule is very similar to ibuprofen, so I expect it would have similar effects.
wool_gather 8y ago
The sodium part of naproxen sodium is a concern for some people.

conanthe 8y ago

Kratom / Cannabis oh wait these are illegal so big pharma can milk their poisons.

mirimir 8y ago
As soon as they're legal enough, they'll be milked too. I mean, you know, analogs tweaked for higher potency, etc.
cycrutchfield 8y ago
Cannabis causes low T and gynecomastia, so not really
- naasking 8y ago
  I looked for studies supporting your statement. The evidence is conflicting, and there appears to be no conclusive evidence one way or the other, although some people certainly are fond of repeating this as if it's fact.
  - sodosopa 8y ago
    Still appears questionable - A few studies and more information included in this article. https://www.mdmag.com/medical-news/is-there-a-link-between-low-testosterone-and-chronic-marijuana-useandrwe https://www.mdmag.com/medical-news/is-there-a-link-between-l...
- conanthe 8y ago
  Citations are "studies" from Nixon era. "Scientists" only could be allowed to study cannabis for bad effects and that was the only way to get funding. This is all crap my friend.
braythwayt 8y ago
Here in Canada, Big Pharma are falling over themselves to get into the Cannabis business. I honestly think the obstacle to Cannabis legalization in the US is social conservatism, not industrial lobbying.

ada1981 8y ago

I just started using CBD, it’s possible it’s just placebo, but I feel no more pain in my joints in the Am, am more relaxed, less anxious, more agreeable and more aware of my body. I’m taking 5Mg capsules 2x a day.

Flashtoo 8y ago

Acetaminophen/paracetamol is really only toxic in higher doses due to its metabolism, as only the intermediate metabolite NAPQI is toxic, but that cannot build up in low doses.

drb91 8y ago
Still, it seems just as easy to have too much of a dose or acetaminophen in a single day as it is to use ibuprofen continually for an extended period of time.

naasking 8y ago

> OTOH acetaminophen is known to be toxic This is news to me. What exactly does "toxic" mean? Do you have a citation I can read? Acetaminophen is not for inflammation anyway.

cyphar 8y ago
Paracetamol (or acetaminophen) can cause liver failure if you take too high a dose[1] (this is one of the reasons you are told not to drink alcohol when taking paracetamol -- if your liver is struggling to process alcohol you're more susceptible to liver failure). In fact, paracetamol poisoning is the primary cause of death in overdoses (in the US, UK, Australia and New Zealand)[2]. And in 2006, [3] found it was the most commonly used compound for intentional overdosing (i.e. suicide by overdose). But of course, this depends on taking a very high dose -- paracetamol isn't dangerous in moderate doses. [1]: https://en.wikipedia.org/wiki/Paracetamol_poisoning https://en.wikipedia.org/wiki/Paracetamol_poisoning [2]: https://www.ncbi.nlm.nih.gov/pubmed/18312195 https://www.ncbi.nlm.nih.gov/pubmed/18312195 [3]: https://www.ncbi.nlm.nih.gov/pubmed/16805658 https://www.ncbi.nlm.nih.gov/pubmed/16805658
- naasking 8y ago
  > Paracetamol (or acetaminophen) can cause liver failure if you take too high a dose Sure, and drinking too much water causes hypernutremia that can also kill you. Toxicity is always dose dependent, so the initial unqualified claim seemed to imply toxicity at normal dosages.
  - cyphar 8y ago
    Botulinum toxin (botox) doesn't kill most people in the standard dosage, but it is obviously toxic (it's in the name). Paracetamol poisoning is fairly common, hypernutremia isn't. Don't get me wrong, I disagree with the original statement that paracetamol is toxic (with the implication that this is a reason not to use it in normal dosages). But it's definitely not harmless.
    - 8y ago

solitus 8y ago

Cannabis with a higher concentration of CBD than THC. I like a ~2:1 ratio.

floatingatoll 8y ago

Ice. (As in, frozen water.)