I suppose you mean that you run tmux locally and then you ssh into a server and run screen remotely? If so, I wonder how hard it would be to make tmux into a c

I suppose you mean that you run tmux locally and then you ssh into a server and run screen remotely? If so, I wonder how hard it would be to make tmux into a client of itself using control mode. I only learned about control mode when I discovered iTerm2's tmux integration, whereby remote tmux windows materialize as "actual" terminal windows on my desktop. However, for the same reason that iTerm2 can resize a window, create a new one, show and hide them, etc, I would _imagine_ it's possible to have your remote tmux windows materialize as tmux windows in your local tmux, and thus would be managed using only a single prefix key. I would guess such a capability would need to be baked into tmux, but I actually wonder how much code would actually be required, since control mode already exists and clearly works quite well.