The styling doesn't change the semantics for the screen reader. Most people who use a screen reader also have some vision so disabling a site's CSS entirely wou

The styling doesn't change the semantics for the screen reader. Most people who use a screen reader also have some vision so disabling a site's CSS entirely would remove meaning that is, intentionally or not, conveyed by the styling. It's more common to modify a site's styling to be more usable, though that's not a reason to skip making a site's styling more accessible to begin with by having sufficient color contrast, large enough text, etc. One bit of styling best avoided because it creates confusion for users operating a site by keyboard is the "order" property used with Flexbox and CSS Grid, it will change the visual order of elements but not their order in the DOM.