3 ms·
There are some groups within the Broad Institute that I think have the tools to more or less resolve the question of the missing heritability (genetic variance)
by carbocation 16y ago
There are some groups within the Broad Institute that I think have the tools to more or less resolve the question of the missing heritability (genetic variance), and I'm sure you know these folks too. This work isn't published yet, so sadly we can't really talk about their answer.
- bhickey 16y agoI don't believe I'm privy to any secrets, but I'll do my best not to leak information. My complaint is with additive models of liability. [In brief compute an independent relative risk for each SNP. To compute the risk of disease, take the log sum of the relative risks.] I haven't seen a model that can take into account epistatic effects.
- carbocation 16y agoBut heritability expressly excludes non-additive factors so I don't think that should be a problem. I agree that non-additivity affects the overall variance.