4 ms·
I haven't read through the whole paper yet (behind a paywall (I think... I'm at a university that subscribes, so I have access) here: http://www.sciencemag.org/
by rflrob 16y ago
I haven't read through the whole paper yet (behind a paywall (I think... I'm at a university that subscribes, so I have access) here: http://www.sciencemag.org/cgi/content/abstract/science.1195271 http://www.sciencemag.org/cgi/content/abstract/science.11952...), but table 1 is somewhat telling: there is no single mutation that's found in all controllers, and not in progressors. Instead, there's a collection of SNPs that controllers have more often than progressors, but not all controllers have any given SNP.
- carbocation 16y agoYou're almost never going to get perfect genetic discrimination in all-or-nothing fashion. The final figure is very interesting: the key SNPs that affect controller status are located near one another in 3-space in the HLA-B binding groove at a key site for antigen presentation. The fact that the genetics are all pointing to specific parts of the molecule in 3-space is extremely helpful.
- electromagnetic 16y agoIt would be interesting to know what would happen if one person had all the SNPs. Would the person be able to cure HIV, or is there a reason there are only combinations present and not the full set (IE does the whole set destroy some other part of immune function)?