3 ms·
Article says they are using an "older method" of gene editing. Well no wonder then, we know that older gene editing methods have a lot of off target effects, cr
by rubatuga 8y ago
Article says they are using an "older method" of gene editing. Well no wonder then, we know that older gene editing methods have a lot of off target effects, crispr cas9 using base modification (instead of deleting whole DNA stretches by splicing) is very safe. This is a FUD article.
- tinus_hn 8y agoPretty likely the same thing was said about that older method.
- ejstronge 8y ago> Article says they are using an "older method" of gene editing. Well no wonder then, we know that older gene editing methods have a lot of off target effects, crispr cas9 using base modification (instead of deleting whole DNA stretches by splicing) is very safe. This is a FUD article. Base editors are a very new (first published in the last two years) and have a whole new class of off-target effects compared to the ‘standard’ Crispr-Cas9 approach, namely editing multiple bases in the targeted regions. I’m not sure why you would say that’s base editing is inherently superior to homologous recombination at the point in time.