The overall generalization lately appears to be that complex traits are encoded in all genes, such that each gene makes a linear contribution to the trait (the

The overall generalization lately appears to be that complex traits are encoded in all genes, such that each gene makes a linear contribution to the trait (the "omnigenic" model). https://www.cell.com/cell/fulltext/S0092-8674(17)30629-3 https://www.cell.com/cell/fulltext/S0092-8674(17)30629-3 https://www.quantamagazine.org/omnigenic-model-suggests-that-all-genes-affect-every-complex-trait-20180620/ https://www.quantamagazine.org/omnigenic-model-suggests-that... For such a system to work, there must be great robustness in the way that traits are encoded. The omnigenic model implies graceful degradation, as also observed in neural networks. Only vanishingly rarely is a single neuron/gene critical.