4 ms·

There is no credible, replicable, evidence that CBD does anything for anyone There are studies that show it is reasonably effective for some intractable forms

There is no credible, replicable, evidence that CBD does anything for anyone There are studies that show it is reasonably effective for some intractable forms of epilepsy https://www.nejm.org/doi/full/10.1056/NEJMoa1611618 https://www.nejm.org/doi/full/10.1056/NEJMoa1611618 Indeed there is an official licensed medicinal version called Epidolex and the FDA recently approved it https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm611046.htm https://www.fda.gov/newsevents/newsroom/pressannouncements/u... (however this often gets overblown somewhat by the pot lobby, so I share your concerns about snake oil in general)

prepend 8y ago
Maybe a more accurate statement is the efficacy of the doses available for retail purchase. The paper you cited used “cannabidiol oral solution at a dose of 20 mg per kilogram of body weight” So for a young adult of 50kg this is 1000mg/day. Amazon’s maximum dose I could find is 1000mg for $50 [0]. So to get these kinds of benefits someone would need $1500/month. I would like to see more studies at the kind of doses these retail doses marketed to grandmas (mine in particular). [0] https://www.amazon.com/Natural-Hemp-Drops-Relief-Essenzia/dp/B07DMCF4FY https://www.amazon.com/Natural-Hemp-Drops-Relief-Essenzia/dp...
- rjbwork 8y ago
  Assuming the stuff is actually safe, I've seen 1000MG for $15.
  - prepend 8y ago
    Please share that link. That would still put the price at $450/month. I don’t know of anything that shows a risk or danger.
- howhireable3141 8y ago
  Yes, it is expensive. I don't know what to tell you other than you are wrong. If you look at your own statements, you will see you stated unequivocally that CBD isn't effective. Now you are backpedaling saying its expensive. Yes, it is expensive. And I promise you it's not hard to see that it absolutely works for some people. If you understood how well cannibinoids fit into our brains, this may not surprise you. Having looked into pricing and done quite a bit of research, the cheapest I have seen for pills is 50c for 25mg. But this is still $600/month for a 1000mg dose. I think most people are taking less than this. But still 300-600mg is expensive. But, its not much more expensive that other "mediciine" that needs to be taken every day.
  - prepend 8y ago
    You might be confusing me with someone else. I never said equivocally or unequivocally that cbd wasn’t effective. I said at retail doses it’s not effective because it’s different than what the study says. A $600/month otc treatment is not realistic. I’m really familiar with retail cbd use. I don’t think it’s harmful. But these retail offerings are not advertising 1g/day doses and instead include droppers and market small doses. I haven’t read any studies that show these low doses having the anecdotal impact. If it absolutely works for some people, then we’ll have RCTs and published results for us both to discuss. That will be great. There’s lots of expensive medicine. There’s also medicine that’s dirt cheap ($6/month metformin, $3/month ssris, etc). With research cbd will be very affordable as well. Because now, it’s only available in the doses in the referenced papers to rich people. Which is nice, but if it is as amazing as folks feel it is then prices really need to come down.
    - howhireable3141 8y ago
      Apologies. I thought it was the same person. However you are wrong that a $600/month otc treatmnet is not realistic. It's certainly not ideal, it's certainly out of the financial range of many people. . And certainly there are people right now spending $600/month for CBD because it works. Prices will definitely come down, and I agree they "need" to. I suspect we will have synthesized CBD quite soon). Minus the black market, and then minus the hype, and then plus the increase in production, prices have a long way to go down.
- EpicEng 8y ago
  So you went from >Placebo is a hell of a drug. There is no credible, replicable, evidence that CBD does anything for anyone, and it's done nothing for many people duped into buying it, it's likely acting as a placebo. To "it works, but it's too expensive." Ok.
  - prepend 8y ago
    I never said that.
    - EpicEng 8y ago
      Well you're right. I assumed it was the same person, my mistake.
      - prepend 8y ago
        Thanks for the response.

prepend 8y ago

Maybe a more accurate statement is the efficacy of the doses available for retail purchase. The paper you cited used “cannabidiol oral solution at a dose of 20 mg per kilogram of body weight” So for a young adult of 50kg this is 1000mg/day. Amazon’s maximum dose I could find is 1000mg for $50 [0]. So to get these kinds of benefits someone would need $1500/month. I would like to see more studies at the kind of doses these retail doses marketed to grandmas (mine in particular). [0] https://www.amazon.com/Natural-Hemp-Drops-Relief-Essenzia/dp/B07DMCF4FY https://www.amazon.com/Natural-Hemp-Drops-Relief-Essenzia/dp...

rjbwork 8y ago
Assuming the stuff is actually safe, I've seen 1000MG for $15.
- prepend 8y ago
  Please share that link. That would still put the price at $450/month. I don’t know of anything that shows a risk or danger.
howhireable3141 8y ago
Yes, it is expensive. I don't know what to tell you other than you are wrong. If you look at your own statements, you will see you stated unequivocally that CBD isn't effective. Now you are backpedaling saying its expensive. Yes, it is expensive. And I promise you it's not hard to see that it absolutely works for some people. If you understood how well cannibinoids fit into our brains, this may not surprise you. Having looked into pricing and done quite a bit of research, the cheapest I have seen for pills is 50c for 25mg. But this is still $600/month for a 1000mg dose. I think most people are taking less than this. But still 300-600mg is expensive. But, its not much more expensive that other "mediciine" that needs to be taken every day.
- prepend 8y ago
  You might be confusing me with someone else. I never said equivocally or unequivocally that cbd wasn’t effective. I said at retail doses it’s not effective because it’s different than what the study says. A $600/month otc treatment is not realistic. I’m really familiar with retail cbd use. I don’t think it’s harmful. But these retail offerings are not advertising 1g/day doses and instead include droppers and market small doses. I haven’t read any studies that show these low doses having the anecdotal impact. If it absolutely works for some people, then we’ll have RCTs and published results for us both to discuss. That will be great. There’s lots of expensive medicine. There’s also medicine that’s dirt cheap ($6/month metformin, $3/month ssris, etc). With research cbd will be very affordable as well. Because now, it’s only available in the doses in the referenced papers to rich people. Which is nice, but if it is as amazing as folks feel it is then prices really need to come down.
  - howhireable3141 8y ago
    Apologies. I thought it was the same person. However you are wrong that a $600/month otc treatmnet is not realistic. It's certainly not ideal, it's certainly out of the financial range of many people. . And certainly there are people right now spending $600/month for CBD because it works. Prices will definitely come down, and I agree they "need" to. I suspect we will have synthesized CBD quite soon). Minus the black market, and then minus the hype, and then plus the increase in production, prices have a long way to go down.
EpicEng 8y ago
So you went from >Placebo is a hell of a drug. There is no credible, replicable, evidence that CBD does anything for anyone, and it's done nothing for many people duped into buying it, it's likely acting as a placebo. To "it works, but it's too expensive." Ok.
- prepend 8y ago
  I never said that.
  - EpicEng 8y ago
    Well you're right. I assumed it was the same person, my mistake.
    - prepend 8y ago
      Thanks for the response.