6 ms·
This is because our mouse models of Alzheimer disease are terrible. And pretty much everything we've tried has been aimed at beta-amyloid. I think there is a
by JamesBarney 8y ago
This is because our mouse models of Alzheimer disease are terrible. And pretty much everything we've tried has been aimed at beta-amyloid.
I think there is a better chance for this therapy because of the way it works, by transition the microglia over to an anti-inflammatory mode.
If this procedure passed safety trials I wouldn't be surprised if a similar therapy worked for schizophrenia, anxiety, and depression.
- jf- 8y agoI agree that various kinds of immune modulation will be a huge part of medicine in the future. Promising results vs cancer, seems plausible you could teach or program the immune system to attack anything in the body once you’ve identified it. Controlling autoimmunity will also be a challenge.
- JamesBarney 8y agoThey've already started doing this with cancer. The problem is the cancer evolves to stop producing the identifiers the immune system was using to determine what to kill.