4 ms·
The situation at hand is not like that. The intended edit will change the function of the gene and its coded protein, that much is known. However, (1) some repo
by subroutine 8y ago
The situation at hand is not like that. The intended edit will change the function of the gene and its coded protein, that much is known. However, (1) some reports are saying the intended edit may not have gone as planned and the gene will actually be completely silenced, and (2) assuming the edit doesnt KO the protein, it will produce a variant that 90% of the population doesnt have. Sure this allele may confer protection against HIV infection, but it may also result in undesirable traits. For comparison the e4 allele of the APOE gene is thought to confer protection against parasites. But it's also found in only 14% of the population. Why might these pathogen protecting alleles not be dominant? Well, wrt the APOE e4 allele, it increases your risk for memory decline and is associated with a 14x rate of Alzheimer's disease. In the 1700s in the South American rainforest u may have opted for the e4 allele, but if you live in a modern society in 2018 where pathogens like parasites and HIV aren't killers, wouldn't you want to avoid the more pertinent risk?