4 ms·
I expect to see a great deal of FUD surrounding human genetic editing the future. One gets the sense, reading the commentary from the scientific community follo
by quotemstr 8y ago
I expect to see a great deal of FUD surrounding human genetic editing the future. One gets the sense, reading the commentary from the scientific community following He Jiankui's announcement, that the outrage and condemnation didn't come from any details of the edit, but instead from a certain disgust at the idea that anyone would attempt to edit human genomes at all.
While it's true that, in theory, unknown edits could cause novel gains of function, and while it's true in theory that there might be undetected off-target effects, these sorts of outcome are unlikely. Mutating one byte of /bin/ls will almost certainly not transform it into a C compiler. Criticism of He Jiankui's work plays up almost-impossible negative side effects while ignoring the beneficial applications of this technology; it emphasizes the remaining areas of genetic ignorance while ignoring the massive strides in understanding from the past decades; and it suggests that we'll never have sufficient understanding to apply these techniques routinely. That is, it's FUD.
Human genetic editing is likely one of the most profoundly beneficial technologies ever developed, and to see its use delayed saddens and disappoints me. If the mainstream scientific community will block the development of this technology, using public condemnation, binding "ethics" panels, and (as I predict will come soon) censorship of research, then the ethical thing to do is to bypass the mainstream scientific community, as He Jiankui did. This work is too important to delay on the account of obsolete, non-utilitarian, and ultimately irrational disgust.
- subroutine 8y agoThe situation at hand is not like that. The intended edit will change the function of the gene and its coded protein, that much is known. However, (1) some reports are saying the intended edit may not have gone as planned and the gene will actually be completely silenced, and (2) assuming the edit doesnt KO the protein, it will produce a variant that 90% of the population doesnt have. Sure this allele may confer protection against HIV infection, but it may also result in undesirable traits. For comparison the e4 allele of the APOE gene is thought to confer protection against parasites. But it's also found in only 14% of the population. Why might these pathogen protecting alleles not be dominant? Well, wrt the APOE e4 allele, it increases your risk for memory decline and is associated with a 14x rate of Alzheimer's disease. In the 1700s in the South American rainforest u may have opted for the e4 allele, but if you live in a modern society in 2018 where pathogens like parasites and HIV aren't killers, wouldn't you want to avoid the more pertinent risk?