Not being able to run all the proprietary software is a given, although I believe Skype is natively supported for the record. I don't run into hardware issue su

Not being able to run all the proprietary software is a given, although I believe Skype is natively supported for the record. I don't run into hardware issue support, though. Especially with something as basic as sound or a second monitor. The worst I've heard recently is that some wireless cards may not be supported because they need proprietary blobs to work. Most things works out of the box since the support is all built into the kernel.