This one is good: http://www.tara.tcd.ie/bitstream/handle/2262/64047/Optimizing%20Interpreters%20by%20Tuning%20Opcode%20Orderings%20%20on%20Virtual%20Machines%2

This one is good: http://www.tara.tcd.ie/bitstream/handle/2262/64047/Optimizing%20Interpreters%20by%20Tuning%20Opcode%20Orderings%20%20on%20Virtual%20Machines%20for%20Modern%20Architectures.pdf;sequence=1 http://www.tara.tcd.ie/bitstream/handle/2262/64047/Optimizin... Though you might not think of hill climbing as "machine learning".