3 ms·

I hadn’t heard that body fat composition affected Alzheimer’s risk. Out of curiosity, do you have a reference?

ekianjo 8y ago
Body fat is a risk for multiple disease. The general idea is that whenever viruses enter the adipose tissue they are hard to reach by the immune system. We dont really understand yet what causes Alzheimer but now there is suspicion of a viral link.
- whatshisface 8y ago
  There is another hypothesis making the rounds that obesity is linked to chronic metabolic stress and eventual damage (so far uncontroversial), which is linked to many separate diseases.
- jodrellblank 8y ago
  internet articles point fingers at long term insulin resistance, e.g. https://www.psychologytoday.com/us/blog/diagnosis-diet/201609/avoiding-alzheimer-s-disease-could-be-easier-you-think?collection=1095953 https://www.psychologytoday.com/us/blog/diagnosis-diet/20160... the receptors responsible for escorting insulin across the blood-brain barrier can become resistant to insulin, restricting the amount of insulin allowed into the brain. While most brain cells don’t require insulin in order to absorb glucose, they do require insulin in order to process glucose. [..] Despite swimming in a sea of glucose, brain cells in people with insulin resistance literally begin starving to death. [..] Which brain cells go first? The hippocampus is the brain's memory center. Hippocampal cells require so much energy to do their important work that they often need extra boosts of glucose. While insulin is not required to let a normal amount of glucose into the hippocampus, these special glucose surges do require insulin, making the hippocampus particularly sensitive to insulin deficits. This explains why declining memory is one of the earliest signs of Alzheimer’s, despite the fact that Alzheimer’s Disease eventually destroys the whole brain. researchers have discovered that Alzheimer’s Disease is preceded by DECADES of gradually worsening glucose hypometabolism. 2012 study showed that a low-carbohydrate high-fat diet improved memory in people with “Mild Cognitive Impairment” (Pre-Alzheimer’s Disease) in only six weeks. https://coconutketones.com/ https://coconutketones.com/ - Dr Mary Newport's work on coconut oil and low carb diet with her husband with early onset alzheimers and dementia, intended to provide an alternative ketone source of fuel for the brain instead of glucose. Grain and sugar elimination: that’s huge, because it’s anti-inflammatory. A big driver of cognitive decline and dementia is inflammation. By going grain-free sugar-free we drop inflammation dramatically. If you were to track inflammatory measures like C-reactive protein or interleukin-6 or tumor necrosis factor (TNFα) or other measures, you would see them drop precipitously, as inflammation recedes, and risk for Alzheimer’s with it. - https://www.wheatbellyblog.com/2017/11/preventing-cognitive-decline-dementia/ https://www.wheatbellyblog.com/2017/11/preventing-cognitive-...
tracker1 8y ago
Alzheimer's is starting to be referred to as Type 3 diabetes that the correlation between metabolic syndrome and the disease is incredibly high. I wonder how much this has to do with the relative uptake of carbohydrate sources and in particular refined sugars (namely fructose) in the typical diet. It seems the more that we learn, the less good refined vegetable oils and the level of fructose intake in people's diets is. I'm not convinced the amount of refined grains people eat is particularly good either. However is seems that sugar (fructose specifically) and refined oils (linoleic acid specifically) are particularly bad in the increased quantities since the early 1900's.

Body fat is a risk for multiple disease. The general idea is that whenever viruses enter the adipose tissue they are hard to reach by the immune system. We dont really understand yet what causes Alzheimer but now there is suspicion of a viral link.

whatshisface 8y ago
There is another hypothesis making the rounds that obesity is linked to chronic metabolic stress and eventual damage (so far uncontroversial), which is linked to many separate diseases.
jodrellblank 8y ago
internet articles point fingers at long term insulin resistance, e.g. https://www.psychologytoday.com/us/blog/diagnosis-diet/201609/avoiding-alzheimer-s-disease-could-be-easier-you-think?collection=1095953 https://www.psychologytoday.com/us/blog/diagnosis-diet/20160... the receptors responsible for escorting insulin across the blood-brain barrier can become resistant to insulin, restricting the amount of insulin allowed into the brain. While most brain cells don’t require insulin in order to absorb glucose, they do require insulin in order to process glucose. [..] Despite swimming in a sea of glucose, brain cells in people with insulin resistance literally begin starving to death. [..] Which brain cells go first? The hippocampus is the brain's memory center. Hippocampal cells require so much energy to do their important work that they often need extra boosts of glucose. While insulin is not required to let a normal amount of glucose into the hippocampus, these special glucose surges do require insulin, making the hippocampus particularly sensitive to insulin deficits. This explains why declining memory is one of the earliest signs of Alzheimer’s, despite the fact that Alzheimer’s Disease eventually destroys the whole brain. researchers have discovered that Alzheimer’s Disease is preceded by DECADES of gradually worsening glucose hypometabolism. 2012 study showed that a low-carbohydrate high-fat diet improved memory in people with “Mild Cognitive Impairment” (Pre-Alzheimer’s Disease) in only six weeks. https://coconutketones.com/ https://coconutketones.com/ - Dr Mary Newport's work on coconut oil and low carb diet with her husband with early onset alzheimers and dementia, intended to provide an alternative ketone source of fuel for the brain instead of glucose. Grain and sugar elimination: that’s huge, because it’s anti-inflammatory. A big driver of cognitive decline and dementia is inflammation. By going grain-free sugar-free we drop inflammation dramatically. If you were to track inflammatory measures like C-reactive protein or interleukin-6 or tumor necrosis factor (TNFα) or other measures, you would see them drop precipitously, as inflammation recedes, and risk for Alzheimer’s with it. - https://www.wheatbellyblog.com/2017/11/preventing-cognitive-decline-dementia/ https://www.wheatbellyblog.com/2017/11/preventing-cognitive-...

tracker1 8y ago

Alzheimer's is starting to be referred to as Type 3 diabetes that the correlation between metabolic syndrome and the disease is incredibly high. I wonder how much this has to do with the relative uptake of carbohydrate sources and in particular refined sugars (namely fructose) in the typical diet. It seems the more that we learn, the less good refined vegetable oils and the level of fructose intake in people's diets is. I'm not convinced the amount of refined grains people eat is particularly good either. However is seems that sugar (fructose specifically) and refined oils (linoleic acid specifically) are particularly bad in the increased quantities since the early 1900's.