You could try the Spyder IDE, which has some similarities to Jupyter. It runs code in IPython, but you write in a regular Python file rather than a notebook. I

You could try the Spyder IDE, which has some similarities to Jupyter. It runs code in IPython, but you write in a regular Python file rather than a notebook. I've used it in exactly the manner you describe, doing a load to memory once, then running and rerunning analyses (or parts of them) in the same Ipython console.