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Yes, you wonder how Alphafold compares with the combined wisdom of Foldit. You start out with a secondary structure prediction from Zhang lab and ask a panel of
by HarryHirsch 8y ago
Yes, you wonder how Alphafold compares with the combined wisdom of Foldit. You start out with a secondary structure prediction from Zhang lab and ask a panel of experienced humans to fold up the protein into a plausible tertiary structure. As a human you have a good idea what larger pieces fit where, but AI still has problems with the large picture, cf. the leopard sofa problem.