4 ms·
I hate providing any negative news for stuff that works for people butt... More and more trials are showing that if you block ampa, ketamine's acute depression
by alexnewman 8y ago
I hate providing any negative news for stuff that works for people butt... More and more trials are showing that if you block ampa, ketamine's acute depression curative properties are completely diminished. Aka, it might work, but it's probably not the right drug
https://clinicaltrials.gov/ct2/show/NCT02911597 https://clinicaltrials.gov/ct2/show/NCT02911597
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487269/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487269/
- xfitm3 8y agoPersonal ancedote: I know someone who has tried this treatment and it has worked for them. First time I’ve heard about ampa blocking.
- derefr 8y agoIIRC (I forget where I read this), ketamine does one thing pharmacokinetically, but its main metabolites—norketamine and dehydronorketamine—have their own entirely-different pharmacokinetics (which aren't just less-potent versions of ketamine's.) I don't know about "not the right drug"; but it might turn out to be considered a pro-drug.
- rhcom2 8y agoThis is important. I was considering a ketamine study but based on the results of naltrexone + ketamine I'm much more cautious and will wait for further studies.