There is a project that does attempt to disentangle musical instruments and voices in the waveform domain that is interesting, http://jordipons.me/apps/end-to-e

There is a project that does attempt to disentangle musical instruments and voices in the waveform domain that is interesting, http://jordipons.me/apps/end-to-end-music-source-separation/ http://jordipons.me/apps/end-to-end-music-source-separation/ ...such that the results could be flanged and recombined separately. But as you hear in their demos, any recombined result would be a Picasso painting as compared to a photograph, maybe interesting though.