2 ms·
Yes, it is very easy to identify paternal mitochondrial inheritance in the current era. The catch is that a very low proportion of the population has mitochondr
by abcc8 8y ago
Yes, it is very easy to identify paternal mitochondrial inheritance in the current era. The catch is that a very low proportion of the population has mitochondrial genomic sequencing (currently). Typically, those who do have their mitochondrial genomes sequenced are those who are suspected of having mitochondrial disease and the prevalence of mitochondrial disease is very low. Of those who are sequenced, the overwhelming majority will have a mutation, that if inherited, is from the mother. I should also add that there are many 'common' mutations that cause the majority of mitochondrial disease and, as expected in a clinical diagnostic setting, these are the most frequently observed and identified molecular diagnoses. Paternal inheritance of mitochondria harboring a disease-causing mutation represents an extraordinarily rare etiology for an already very rare disease.