3 ms·
> IIRC the BGI IQ sequencing initiative did not lead to any meaningful discoveries The BGI initiative led to no meaningful discoveries because of internal disa
by gwern 8y ago
> IIRC the BGI IQ sequencing initiative did not lead to any meaningful discoveries
The BGI initiative led to no meaningful discoveries because of internal disarray & politics & strategic missteps meant that it was never completed; if it had, it probably wouldn't've reported much because they made a failed bet that common variation would be unimportant and it would be more efficient to look for rarer variants which boosted IQ a lot in a few thousand high-IQ participants rather than the 100,000+ that would be necessary using normal people.
We now know that there appear to be no such variants. Common variants with n>100k yielded the first successful IQ GWAS with Rietveld et al 2013 (0.3% variance). GWASes kept getting bigger and better, and the latest one, Allegrini et al 2018 (https://www.biorxiv.org/content/early/2018/09/17/418210 https://www.biorxiv.org/content/early/2018/09/17/418210), can now predict 11% of variance in IQ/16% EDU.
> since it's not yet obvious or fully proven yet that IQ is that heritable.
It is, and it says a lot that so many people have such a mistaken impression.
- ramraj07 8y agoWell I suppose my appraisal of the field is a few years old, thanks for the reference, will go through it.