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There is no human with all the positive variants; it is the the distribution of these variants that explains 5.2%. GM would allow you to create such a human. T
by wycs 8y ago
There is no human with all the positive variants; it is the the distribution of these variants that explains 5.2%. GM would allow you to create such a human.
That paper does not imply what you think it implies: that editing all these variants in an individual embryo would have a small effect.
An individual with the top 200 IQ-enhancing variants edited in (and an otherwise normal genome) would be far, far smarter than than than you seem to think, even though the variants edited only explain 5.2% of the differences within the population.
- skosuri 8y agoAhh I see, you are just making stuff up.
- wycs 8y agoNo. I think the claim "one can raise IQ several standard deviations by editing <200 alleles" is likely true:https://arxiv.org/pdf/1408.3421.pdf https://arxiv.org/pdf/1408.3421.pdf
- skosuri 8y agoYeah, know his work, and I don't think he'd agree with you: http://www.genetics.org/content/210/2/477 http://www.genetics.org/content/210/2/477
- carbocation 8y agoThere is a lot to unpack here. But this is basically science fiction, given how far out we are from understanding how to cosmetically modify complex traits in this way.