2 ms·
[2] wont work on a whole genome because of the many differences present between mammals after millions of years of evolution. The "alignment" of a small sequen
by Real_S 8y ago
[2] wont work on a whole genome because of the many differences present between mammals after millions of years of evolution. The "alignment" of a small sequence may be confused between human and mouse, but not longer sequences and definitely not whole genomes (alignment using a tool like BLAST or BLAT).
I wrote a summary of genetic information discussing this very idea. See the PDF under "What is Genetic Info?", read the Phylogenetics section:
https://www.geneinfosec.com/more-info/ https://www.geneinfosec.com/more-info/
- Gatsky 8y agoNo this is not correct, look up modern whole genome pipelines. Standard read lengths are 75-150 base pairs. Whole genome alignment has never been done with BLAST or BLAT (this would take an extremely long time). BWA is most commonly used. Running the standard data pipeline on a mouse human mixture will cause many mouse sequences to be aligned to the human genome.