4 ms·
Do you need to keep increasing the dosage? Or have you found a long-term dosage that despite tolerance, it still maintains a reasonable degree of efficacy?
by iliketosleep 8y ago
Do you need to keep increasing the dosage? Or have you found a long-term dosage that despite tolerance, it still maintains a reasonable degree of efficacy?
- GordonS 8y agoNo, I've been on the same dosage for years. I mentioned in another comment that I take magnesium, which is an NMDA antagonist, and there is a lot of evidence that these prevent the buildup of tolerance. I don't know if that's why I can remain on the same doseage, or if it's simply that I always stick to the prescribed dose.
- viggity 8y agomagnesium sulfate? citrate? dose?
- GordonS 8y agoI take citrate, which I initially chose for it's laxative effects. Not sure if it's the most effective for reducing tolerance. Agmatine is a more potent NMDA antagonist, but is unfortunately no longer available in the EU, due to the fairly 2017 Novel Food Regulation[1] [1] https://ec.europa.eu/food/sites/food/files/oc_oof_analysis_main_outcome_en.pdf