12 ms·
This treatment kills only temperature sensors, so I'm guessing it would only help with a "burning sensation". Killing nerve tissue can backfire when neurons hi
by NPMaxwell 8y ago
This treatment kills only temperature sensors, so I'm guessing it would only help with a "burning sensation".
Killing nerve tissue can backfire when neurons higher up start compensating for the lack of signal from neurons below (1). The result can be more painful and harder to treat.
The randomized controlled experiment with dogs was for bone cancer and the treatment appears to increase days until euthanasia about 60% (2). That's a real benefit, but not related to runner's knee, which is often related to the ITB band. For possible treatments, see (3)
1. https://en.wikipedia.org/wiki/Phantom_limb https://en.wikipedia.org/wiki/Phantom_limb
2. https://en.wikipedia.org/wiki/Phantom_limb https://en.wikipedia.org/wiki/Phantom_limb
3. https://www.runnersworld.com/advanced/a20844564/treating-itbs/ https://www.runnersworld.com/advanced/a20844564/treating-itb...
- Real_S 8y agoThe TRPV1 receptor is present on sensory nerves, so although it does primarily detect high temperature[1], regulating it can result in pain relief in general, not just a reduction in "burning sensations." Also, the article simplifies the rather complicated molecular biology, much of which is still being worked out. Importantly the article does not discuss killing nerves, just their nerve endings. [1]TRPV1 also detects high acidity and the endocannabinoid anandamide. https://en.wikipedia.org/wiki/TRPV1 https://en.wikipedia.org/wiki/TRPV1 PS: Your links [1] and [2] are identical... mistake?
- NPMaxwell 8y agoThanks! Both for the clarification and noting the mistake. Here's the original article: (2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431903/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431903/
- Real_S 8y agoInteresting... so it looks like RTX can cause cell death. Perhaps this shouldn't be surprising. Glad you updated that link.