As someone who used to use ROOT, I would strongly recommend against it. Its C++ implementation has all manner of hidden state, and this leaks into PyROOT. For

As someone who used to use ROOT, I would strongly recommend against it. Its C++ implementation has all manner of hidden state, and this leaks into PyROOT. For example, ROOT has the concept of ownership, entirely distinct from the python sense of references. A file owns the histograms that were read from it. Closing the file changes all references to histograms read from that file to None. It took a large amount of digging to figure out how that was even possible (overwriting an existing object from within the C API), but I cannot for the life of me understand why. ROOT has way too many gotchas for me to ever recommend it.