I agree with you, but I would like to qualify that. The low hanging fruit analogy is apt in more ways than one; there are likely to be deeper truths out there t

I agree with you, but I would like to qualify that. The low hanging fruit analogy is apt in more ways than one; there are likely to be deeper truths out there that we don't know enough to model; take dark matter and dark energy and the expanding universe for one. In that respect I disagree that "the big fundamental structures ... are more or less known" However, these fruits of science are so far out of reach of humanity's experience that they will be very difficult to exploit. Personally, I think that the social sciences have yet to see their renaissance. The social sciences involve complex systems that are difficult to model, so there simply aren't comprehensive quantitative theories in these fields on the order of physics. If we develop efficient, cheap computation, orders of magnitude greater than what we currently have,[1] perhaps the social sciences may see its heyday.