I see the PO box question every time this discussion comes up. For starters, you'd have to be okay with living a lie to your coworkers and putting your career

I see the PO box question every time this discussion comes up. For starters, you'd have to be okay with living a lie to your coworkers and putting your career at risk if you ever let the facade slip. You can't ever talk about local events at the virtual water cooler. Do you live in the same time zone as one of the high-cost-of-living cities? If not, you can't ever mention what time your kids go to school either. Is your employer ever going to fly you out to conferences or all-hands meetings? They're either buying your plane ticket directly or expecting to see a receipt; good luck explaining why you never fly out of your "home" airport. Does your employer report your earnings to the IRS? If so, you'll likely be committing some sort of tax evasion or at least having to submit a ton of corrective paperwork each year. Do they provide insurance? You'll have to explain to the provider why your address isn't what your company thinks it is or else risk voiding your coverage and/or committing insurance fraud. And so on, and so forth. All in all, it's probably doable, but very few people would consider it worth the effort unless they are pathologically inclined towards fraud in the first place.