I don't think anyone has mentioned it apart from the fact most people would find these confusing, but these types of layouts look like accessibility nightmares,

I don't think anyone has mentioned it apart from the fact most people would find these confusing, but these types of layouts look like accessibility nightmares, and for what benefit? Making something look a bit nicer? I mean, it's fine if the main goal of the website is to be artistic, but as others have pointed out, that's not the main goal of most websites, it's communicating information.